Can you slow cook a pot roast too long?

Chef's answer
If you've added liquid to the cooker, the food may get more tender if it's cooked for too long, because the liquid doesn't boil away like it does in other methods of cooking. However, you could also end up with a tough pot roast. ... All in all, you could end up with a mushy or tough pot roast if you cook it too long.
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