Why do my homemade hamburgers fall apart?

Chef's answer
If you try to flip it too soon before the meat has had a chance to fully cook on one side, the meat won't be done enough on that side to hold the rest of the patty together, and it will fall apart much easier.
Frequently asked Questions 🎓
Similar story if it was frozen and then defrosted
The most common reason as to why your meatloaf may fall apart is that it doesn't have enough binding agents, like eggs and breadcrumbs. These ingredients are key because they're what makes the meat mixture stick together and stay together while it cooks.9 Nov 2020
How Long to Cook Corned Beef in the CrockPot. Cook in the slow cooker on high for closer to 6 hours. Most recipes recommend you cook the brisket for 4 to 4 1/2 hours on high in the slow cooker. In doing so you'll have nicely cut portions that while tender, simply don't fall apart when stuck with a fork.
Preheat Smoker Grill to 170 degrees F. Cooking at a low temperature will make the wood smoke more. Place the brisket (in roasting pan) in the smoker and close the smoker lid. Smoke the brisket for 1 hour for every pound of meat or smoke overnight.
Why are my Salmon Patties falling apart? ... The salmon patties will fall apart if they are too wet. You need enough cracker crumbs to bind all the ingredients together. So that the patties will hold together and not fall apart.26 May 2020
Similar story if it was frozen and then defrosted
If the meat falls off the bone, it's overcooked. It should have a little chew to it. On the other hand, if the meat doesn't pull away from the bone, it's undercooked.1 Jul 2018
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